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KMID : 1035220160080020088
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Korean Journal of Neuromuscular Disorders
2016 Volume.8 No. 2 p.88 ~ p.91
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A Case of Acute Neuropathy Associated with Low Thiamine Level Following Treatment with Arsenic Trioxide for a Patient with Acute Promyelocytic Leukemia
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Yoon Jee-Eun
Sunwoo Jun-Sang
Kim Ji-Sun
Lee Kyung-Bok
Ahn Moo-Young
Roh Hak-Jae
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Abstract
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Arsenic trioxide has been steadily used as a treatment for acute promyelocytic leukemia over the decade. Peripheral neuropathy is a common complication of arsenic therapy and the symptoms are usually mild and reversible following discontinuation of the therapy. However, the clinical course of arsenic neurotoxicity in patient with coexistence of thiamin deficiency may potentially lead to be severe weakness and bad prognosis. It is important to determine the serum thiamine level of patients with acute promyelocytic leukemia before administrating Arsenic trioxide.
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KEYWORD
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Arsenic trioxide, Thiamine level, Peripheral neuropathy
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